Biography

Hello! I am a biostatistician and R developer in the Department of Biostatistics at Vanderbilt University Medical Center. My primary collaboration is with the Vanderbilt Memory & Alzheimer’s Center, a team of clinicians and scientists committed to uncovering how cardiovascular health affects Alzheimer’s disease pathology and cognitive decline in older adults. I use the R programming language to conduct statistical analyses that employ a modern approach. Methods I commonly use include mixed-effects regression models, nonparametric bootstrap resampling, and mediation analysis. I like using R because I’m able to combine R code with Markdown, $\mathrm{\LaTeX}$, and JavaScript to create dynamic, reproducible reports; it has an active community of open-source developers that I love participating in; and it is a functional programming language that is fun to use.

In addition to conducting statistical analyses, I create software tools that address unique challenges arising from collaborations between statisticians and other scientists. Examples of these tools include a research package that automates the highly complex process of generating a master dataset, a package that allows the user to create a codebook to accompany the sharing of a dataset, and a web app that lets users perform basic exploratory data analysis without needing to write any code or submit a statistical request.

Outside of my work, I like to study languages, cook, and play video games. Please feel free to shoot me an email if you would like to chat!

Interests
  • Functional Programming
  • Research Software Development
  • Reproducible Research
  • Mixed-Effects Models
  • Mediation Analysis
Education
  • Master of Applied Statistics, 2016

    The Pennsylvania State University

  • Bachelor of Science, Biochemistry, 2007

    Southern Methodist University

Recent Publications

(2021). Elevated aortic pulse wave velocity relates to longitudinal grey and white matter changes. Submitted to Arteriosclerosis, Thrombosis, and Vascular Biology.

(2021). Axonal injury partially mediates associations between increased left ventricular mass index and white matter damage. Submitted to Stroke.

(2021). Lower cerebral oxygen utilization is associated with Alzheimer's disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers. Submitted to Journal of Cerebral Blood Flow and Metabolism.

(2021). Subclinical compromise in cardiac strain relates to smaller cerebral grey matter volumes in older adults. Submitted to PLOS One.

(2020). Cerebrospinal fluid biomarkers of neurodegeneration, synaptic dysfunction, and axonal injury relate to atrophy in structural brain regions specific to Alzheimer's Disease. Alzheimer’s & Dementia.

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(2020). Lower cardiac output relates to longitudinal cognitive decline in aging adults. Frontiers in Psychology.

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(2019). Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring.

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(2019). Increased blood pressure visit-to-visit variability in patients with systemic lupus erythematosus: association with inflammation and comorbidity burden. Lupus.

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(2019). Increased incidence of resistant hypertension in patients with systemic lupus erythematosus: a retrospective cohort study. Arthritis Care & Research.

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(2018). Subclinical compromise in cardiac strain relates to lower cognitive performances in older adults. Journal of the American Heart Association.

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(2006). Regioselective one pot synthesis of 2-alkyl/aryl-4H-benzo[1,4]thiazine-3-one via microwave irradiation. Journal of Heterocyclic Chemistry.

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(2006). Synthesis of 4,4-disubstituted-4H-benzo[d][1,3]oxathiin-2-ones, a new class of compounds. Synthetic Communications.

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