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Cerebrospinal fluid biomarkers of neurodegeneration, synaptic dysfunction, and axonal injury relate to atrophy in structural brain regions specific to Alzheimer's Disease

**Introduction:** Patterns of atrophy can distinguish normal cognition from Alzheimer's disease (AD), but neuropathological drivers of this pattern are unknown. This study examined associations between cerebrospinal fluid biomarkers of AD pathology, …

Lower cardiac output relates to longitudinal cognitive decline in aging adults

**Background:** Subclinical reductions in cardiac output correspond to lower cerebral blood flow (CBF), placing the brain at risk for functional changes. **Objectives:** This study aims to establish the consequences of reduced cardiac output on …

Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition

**Introduction:** Neuroaxonal damage may contribute to cognitive changes preceding clinical dementia. Accessible biomarkers are critical for detecting such damage. **Methods:** Plasma and cerebrospinal fluid (CSF) neurofilament light (NFL) were …

Increased blood pressure visit-to-visit variability in patients with systemic lupus erythematosus: association with inflammation and comorbidity burden

**Background:** Blood pressure visit-to-visit variability is a novel risk factor for deleterious long-term cardiac and renal outcomes in the general population. We hypothesized that patients with systemic lupus erythematosus (SLE) have greater blood …

Increased incidence of resistant hypertension in patients with systemic lupus erythematosus: a retrospective cohort study

**Objective:** To compare the risk of resistant hypertension (RHTN) in patients with systemic lupus erythematosus (SLE) and in controls without SLE, and to define factors associated with RHTN in patients with SLE. **Methods:** We studied 1,044 …

Subclinical compromise in cardiac strain relates to lower cognitive performances in older adults

**Background:** Global longitudinal strain (GLS), reflecting total shortening of the myocardium during the cardiac cycle, has emerged as a more precise myocardial function measure than left ventricular ejection fraction (LVEF). Longitudinal strain …

Regioselective one pot synthesis of 2-alkyl/aryl-4H-benzo[1,4]thiazine-3-one via microwave irradiation

A series of 2‐alkyl/aryl‐4H‐benzo[1,4]thiazine‐3‐ones have been synthesized by microwave irradiation of ethyl‐2‐bromo‐2‐alkyl/aryl acetate and 2‐amino thiophenol in the presence of 1,8‐diazabicyclo‐[5.4.0] undec‐7‐ene and N‐methylpiperidine. All …

Synthesis of 4,4-disubstituted-4H-benzo[d][1,3]oxathiin-2-ones, a new class of compounds

4,4‐Dialkyl and 4,4‐diaryl‐4H‐benzo[d][1,3]oxathiin‐2‐ones were synthesized by the reaction of 2‐(mercapto‐phenyl)‐dialkyl‐ (or diaryl)‐methanol with CDI in excellent yield. The 2‐(mercaptophenyl)‐dialkyl‐ (or diaryl)‐methanols were prepared by the …