**Introduction:** Matrix metalloproteinases (MMPs) regulate extracellular matrix remodeling and blood-brain barrier permeability, but associations with white matter integrity are unknown. This study relates cerebrospinal fluid (CSF) biomarkers of …
**Objective:** To determine whether baseline aortic stiffness, measured by pulse wave velocity (PWV), relates to longitudinal cerebral grey or white matter changes among older adults given aortic stiffness. **Methods:** Vanderbilt Memory and Aging …
**Background and Purpose:** Left ventricular (LV) mass index is a marker of subclinical LV wall remodeling that relates to white matter damage in aging, but the molecular pathways underlying this association are unknown. This study assessed if LV …
**Objective:** To determine whether baseline aortic stiffness, measured by pulse wave velocity (PWV), relates to longitudinal cerebral grey or white matter changes among older adults given aortic stiffness. **Methods:** Vanderbilt Memory and Aging …
Oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) are markers of oxygen homeostasis that may offer insights into abnormal changes in brain aging. The present study cross-sectionally related OEF and CMRO2 to cognitive …
**Background:** Global longitudinal strain (GLS) is a sensitive measure of regional myocardial function that is associated with cognition in older adults. This study examined if compromised GLS related to structural brain changes among aging adults …